Clobetasol propionate and its Applications in Dermatology

Clobetasol propionate and its Applications in Dermatology - A Snapshot

- Clobetasol propionate, commonly referred to as clobetasol, is an ultrapotent topical corticosteroid used to treat various severe inflammatory skin conditions due to its strong anti-inflammatory and immunosuppressive properties.

- Clobetasol is available commercially in multiple formulations overseas, but not in Australia. These include creams, ointments, gels, lotions, and foams, all typically containing 0.05% clobetasol propionate.

- Clobetasone butyrate, which is available over-the-counter in pharmacies as Eumovate, is not equivalent to clobetasol and is considered to be a mild topical steroid.

- Clobetasol is primarily used in Australia to manage severe inflammatory skin disorders, including psoriasis, eczema, lichen planus, discoid lupus erythematosus, and alopecia areata.

- Clobetasol is sometimes compounded with other agents to enhance its effectiveness for treating various conditions.

         - Formulations with 3-10% salicylic acid to help remove scale and improve steroid penetration in psoriasis and scaly conditions (e.g Clobenov-S available overseas).

         - Clobetasol 0.05% combined with calcipotriol 0.005% (e.g Sorvate-C) used to treat chronic plaque psoriasis.

         - Formulations with antifungal and antibacterial agents such as ketoconazole and neomycin to treat infected inflammatory lesions such as kerion (e.g Kenazole Plus available overseas).

- Typical usage involves applying a thin layer of clobetasol to the affected area once or twice daily, depending on the severity of the condition.Due to its potency, clobetasol is generally prescribed for short-term use to avoid potential side effects such as cutaneous atrophy or adrenal suppression. Patients should be instructed to wash their hands thoroughly after use and to avoid contact with the eyes, face or flexural sites.